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What is amyotrophic lateral sclerosis?

Stem Cell Treatment For Cerebral Palsy

What is amyotrophic lateral sclerosis?

Amyotrophic Lateral Sclerosis degenerates nerve cells that are involved in voluntary muscle actions called motor neurons. These are actions that we can control such as those in the arms, legs & face. Motor neurons are located in the brain & spinal cord. As ALS becomes severe, these cells degenerate & die. They cease sending messages to muscles. The brain can no longer control voluntary movements & as a result muscles weaken. As the disease escalates, it affects more & more voluntary muscles. The person loses control over their arms, face & legs. With time, the lack of ability to breathe without external support can lead to respiratory difficulties. There is no cure as such, but symptoms can be relieved with treatment & quality of life can be improved. Some key points of ALS
  1. ALS (Amyotrophic Lateral Sclerosis) affects nerve cells in the brain & spinal cord, leading to muscle weakness, loss of motor function, paralysis, breathing issues & eventually death.
  2. Most people with ALS will live between three & five years after symptoms appear.
  3. The exact cause is not known, but environmental & genetic factors may be involved.
  4. Nowadays there is no cure & treatment that aims to take over from symptoms, provide social & emotional support & perhaps slow disease progression.

Stem cell ALS Treatment

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Causes of ALS

As for the exact cause of ALS, it is still not clear to the medical world. But the following possible causes are found.

  1. Disorganized immune response – The immune system may attack some of the body’s cells, possibly killing nerve cells.
  2. Chemical imbalance – People with ALS (Amyotrophic Lateral Sclerosis) frequently have high levels of glutamate, a chemical messenger in the brain. Glutamate in high amounts is known as toxic to nerve cells.
  3. Mis-handling of proteins – If proteins are not processed correctly by nerve cells, abnormal proteins could potentially accumulate & cause the nerve cells to die.

Possible environmental factors

The environment may also play a vital role in the spread of the disease such as:

  1. mechanical or electrical trauma
  2. military service
  3. high levels of exercise
  4. high levels of agricultural chemicals
  5. high levels of a variety of heavy metals

However, there is no tangible evidence to prove that definite lifestyle changes can lower the risk of the disease.

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